At the Core of Life

At the Core of Life

Hydrogen is a major constituent of any life form and represents more than three of every five atoms in animal species, and just under half of all the atoms in plants. Hydrogen, both its protons and electrons, appears to not only enable, but also optimise energy production by mitochondria and chloroplast. The significance of hydrogen in biology cannot be underestimated as it is part of the very first step in mitochondrial function as well as the last, be it part of a proton pump, the transfer of electrons, and the completion of redox balance and homeostasis.

The mitochondrion is the main source of ATP (adenosine triphosphate) and is an essential organelle of plants, animals and fungi that divide independently from the cells and have their own genome. Their primary function is to provide energy to the cell in the form of ATP using oxygen by a process called cellular respiration. In addition, mitochondrion can forgo the production of ATP to produce heat in brown fat tissue contributing to thermoregulation, and is also involved in other critical tasks, such as signalling, maintaining control of the cell cycle, cell growth, cellular differentiation, and even cell death.

 

There is an estimated 37.2 trillion cells in the body and each cell contains between 2 and 2500 mitochondria each possessing a 17000 ATP assembly line. It is estimated that there are about 10 million billion (10,000 trillion) mitochondria in an adult human! The oxidative phosphorylation of one molecule of glucose consumed by the cell results in the production of 32 ATP by the mitochondrion.

 

Molecular hydrogen supplementation has the ability to increase mitochondrial ATP production by more than 50% while decreasing the production of superoxide by the first respiratory complex. The ability to increase the production of ATP while reducing the production of reactive oxygen species, thus reduces the need to repair the damage they cause, represents an advancement in biology that could not be more relevant in today’s world.

Peer-reviewed scientific documents now run into the thousands. Taken collectively they clearly identify that the deficiency of hydrogen in biological organisms costs the world well over 100 trillion dollars in lost income every single year. It underpins the health potential and lifespan of all things, and ultimately our entire biosphere (including its climate) as we know it. From a scientific viewpoint it is only now that we are beginning to understand the importance of molecular hydrogen in biology and its tremendous benefit.

 

What Is Hydrogen Biology?

We are dedicated to globally significant biological challenges that affect all of us in every way. We believe that the following information and technology relevance represents the single most significant potential impact in the world today, as it affords us with a simple biological solution to the ever-increasing stressors that impact our lives.

While the global hydrogen focus seems to be around energy production to power our transport and service needs, we believe the big story is its relevance to biology and its role in all living things. The total value of the hydrogen energy sector (an estimated 8 trillion dollars) pales compared to the 100 trillion dollars plus estimate when considering the relevance associated with the hydrogen biology sector. The significance and diversity of this must not be underestimated. The use of hydrogen and oxygen supplementation will define improvements in food production and health for the next hundred years. Our world is about to witness an inevitable evolutionary step in what will be new standards of health, productivity, sustainability, and healing.

Molecular Hydrogen (H2) and Oxygen administration in the form of gas inhalation, the consumption and application of oxy-hydrogen enriched water, and the perfusion of an enriched saline solution have shown tremendous positive biological effects in the medical and agricultural fields for the last 15 to 20 years. Importantly, Molecular Hydrogen is inherently non-toxic and can be safely used in the medical and agricultural fields amongst others.

It was first suggested with humour in Nature (1996) as a natural antioxidant and selective scavenger of oxygen free radicals to treat oxidative stress. More recently, it has been broadly indicated that molecular Hydrogen exerts its biological effects in two major ways. The first one is the scavenging of free radicals, and the other is modulating specific gene expression or signalling pathways, both in animals and plants. Molecular Hydrogen has been demonstrated to induce change in gene expression leading to anti-oxidative, anti-inflammatory, and anti-apoptotic responses in all organisms tested without any detrimental side effects. Thus, molecular Hydrogen enables the organism to reduce and withstand stress longer and better while thriving.

However, the very latest discovery take this even further and indicates that it is at the very core of multicellular life that is positively affected. Molecular hydrogen could be donating electrons in the Q chamber of complex I to the ubiquinone thereby shortening the electron transfer chain in complex I. In consequence, the production of superoxide radicals by this complex is decreased while the proton pump activity is maintained. Molecular hydrogen, both the protons and electrons, supplemented to the mitochondria and complex I, ultimately results in a proton gradient increase, and the increased proton gradient generated, will result in an increased production of ATP.

The enormous potential that Molecular Hydrogen and Oxygen supplementation has identified to affect and determine outcomes for, includes:

  • Mitochondrial Function
  • The increased production of ATP
  • Oxidative Stress and its management
  • Immune Cell Recovery
  • Inflammation and inflammatory Response
  • NF-kB Protein Complex

A simple google scholar search for oxidative stress returns 3 million papers, while a search for inflammation returns a further 4 million documents. Such tremendous numbers highlight the societal importance of these two challenges alone. It is why any possible way to moderate inflammation and oxidative stress, such as with the use of molecular hydrogen, should be investigated thoroughly given the considerable cost-benefit ratio it represents.

Oxidative stress and inflammation represent huge costs and production losses in agriculture through livestock, plant health and growth. While inflammation decreases the growth rate and productivity of livestock, oxidative stress is a by-product of abiotic stress in plants which limits growth, reduces flowering potential, production, and business returns.

Molecular Hydrogen supplementation however, increases the resilience of livestock to pathogens, decreases inflammation and improves plant tolerance to abiotic and biotic stresses. This results in positive effects on germination, seedling growth, accelerated root growth and development of plant crops when utilising Hydrogen and Oxygen enriched water. Furthermore, there is numerous reports of improved nutritional value and post-harvest quality of these agricultural products making them more desirable in the marketplace. This can all be achieved while using less biotic intervention and mineral/chemical inputs, ultimately reducing costs while improving quality. Furthermore, it leads to less waste, runoff, and contamination to the surrounding environment such as land, rivers, oceans, and the wildlife that live thereon and in.

Finally, there is the value-adding potential that soil supplemented with Hydrogen leads to carbon sequestration by encouraging root systems and organic matter back into the earth and similarly boosting soil microbial community likened to what is achieved by planting legumes. Enabling access to the biological gasses of life creates a favourable environment capable of sustaining life. This is precisely the shift needed when regenerating contaminated or unproductive land, whether salt-affected, heavy metal contaminated, desolated or monoculture-based farmland, where the soil has deteriorated to such an extent that it has become just lifeless dirt. Creating a favourable environment for life to live is the key to carbon sequestration and the future we seek.

No matter what strategy one decides to implement for whatever biological improvement they are looking to achieve, hydrogen will remain the single biggest piece of the puzzle and must be considered as part of the solution.

  1. Jones, D. Gas therapy. Nature 383, 676 (1996).
  2. Ohta, S. Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des 17, 2241-2252 (2011). PMID:21736547;
    http://dx.doi.org/10.2174/138161211797052664
  3. Dong, Z. & Layzell, D. B. H2 oxidation, O2 uptake and CO2 fixation in hydrogen treated soils. Plant and soil 229, 1-12 (2001). 10.1023/A:1004810017490
  4. Dong, Z., Wu, L., Kettlewell, B., Caldwell, C. D. & Layzell, D. B. Hydrogen fertilization of soils–is this a benefit of legumes in rotation. Plant, Cell & Environment 26, 1875-1879 (2003). 10.1046/j.1365-3040.2003.01103.x

 

Mitochondrial Function

The mitochondrion is an essential organelle of plants, animals and fungi that divide independently from the cells, and have their own genome. Their primary function is to provide energy to the cell in the form of ATP using oxygen by a process called cellular respiration. In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signalling, cellular differentiation, and cell death. The mitochondrion also maintains control of the cell cycle and cell growth.

Cellular respiration is a catabolic pathway that breaks down glucose and other molecules to ultimately produce ATP. The stages of cellular respiration include glycolysis, pyruvate oxidation, the citric acid or Krebs cycle, and oxidative phosphorylation that uses oxygen as a terminal electron acceptor. However, the process is very complex and sensitive and is at the origin of the accidental production of reactive oxygen species. Thus, the mitochondrion is also the centre of oxidative stress where the most potent free radical, the hydroxyl radical, is produced.

Ohsawa et al. (2007)1 demonstrated that Hydrogen gas could scavenge the hydroxyl radical in live cells. By scavenging the Hydroxyl radical molecular hydrogen decrease oxidative stress in vivo. Furthermore, Ishihara et al. (2019)2 demonstrated that Hydrogen supplementation suppressed superoxide production by complex I, a prominent radical that forms an equilibrium with the perhydroxy radical (HO2). Furthermore, Ishihara et al (2019) propositions that H2 could donate electrons the Q chamber taking together with the work of Zhang et al that shows H2-evolution by complex I, shows that Complex I could be using H2 directly to enable the pumping of protons from the matrix to the intermembrane space, increasing the potential ATP production without using substrate originating from the degradation of glucose. Indeed, Gvozdjáková et al. (2020) report an increase of more than 50% in ATP production in presence of H2 compared to control.

Furthermore, under high energetic demand the cell switches to aerobic glycolysis and lactate production, however, this switch is supposed to be transient and the longer it persists the more reactive oxygen species are produced resulting in oxidative stress and damage to the mitochondria. Molecular hydrogen supplementation is capable of reversing this metabolic pathway switch from aerobic glycolysis to oxidative phosphorylation representing significant consequential benefits.

  1. Ohsawa, I. et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13, 688-694 (2007). PMID:17486089;
    http://dx.doi.org/10.1038/nm1577
  2. Ishihara, G., Kawamoto, K., Komori, N. & Ishibashi, T. Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential. Biochem Biophys Res Commun 522, 965-970 (2020). PMID:31810604;
    http://dx.doi.org/10.1016/j.bbrc.2019.11.135
  3. Gvozdjáková, A. et al. A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats. Canadian Journal of Physiology and Pharmacology 98, 29-34 (2020). 10.1139/cjpp-2019-0281
  4. Xin Zhang et al. Mitochondria in higher plants possess H2 evolving activity which is closely related to complex I. arXiv:2001.02132
  5. Niu, Y. et al. Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch. Sci Rep 10, 1962 (2020). PMID:32029879;
    http://dx.doi.org/10.1038/s41598-020-58999-0
  6. Cassim, S., Vučetić, M., Ždralević, M. & Pouyssegur, J. Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer. Cancers (Basel) 12, E1119 (2020). PMID:32365833;
    http://dx.doi.org/10.3390/cancers12051119

Oxidative Stress

Approximately 40 years of research have resulted in about 3 million research papers identifying the challenges that oxidative stress represents. These challenges result in tens of trillions of dollars of economic and social losses each and every year around the world. Oxidative stress refers to elevated intracellular levels of Reactive Oxygen Species (ROS) that cause damage to lipids, proteins and DNA. Oxidative stress results from an imbalance of ROS and antioxidants in a living organism, such as alpha-lipoic acid, glutathione and hydrogen. 

Oxidative stress occurs naturally as the result of the normal function of the organism but can also be potentiated by environmental and pathological pressures while also playing a direct role in the ageing process. Reactive oxygen species are molecules that “want” to capture electrons from others to stabilise themselves. Because they are highly reactive, they will steal electrons from any source close to them, such as proteins and DNA, which damages the stability and function of the donating molecule. The major cellular source of ROS is the mitochondria.

In response to this, antioxidants are molecules that can donate electrons without becoming reactive themselves. This is the role molecular hydrogen plays. Antioxidants stop the oxidation pathway by “reducing” the oxidant, preventing damage. Antioxidants are produced internally by our bodies and can also be found in food. All antioxidants however are not equal. For example, the size of the antioxidant molecules will determine where they can go and where they cannot. It is often true that the smaller the molecule, the faster it can potentially reach all corners of a body.

One such powerful antioxidant that can passively diffuse through the living body (or plant) at great speed is molecular Hydrogen. Furthermore, organisms produce the enzymes Superoxide Dismutase (SOD) and Catalase, that catalyse the safe conversion of superoxide into molecular oxygen and oxygen peroxide, while the catalase converts hydrogen peroxide into water and molecular oxygen. Interestingly the exposure to hydrogen increases significantly the activity of both enzymes further potentiating the antioxidant system.

  1. Pisoschi, A. M. & Pop, A. The role of antioxidants in the chemistry of oxidative stress: A review. Eur J Med Chem 97, 55-74 (2015). PMID:25942353;
    http://dx.doi.org/10.1016/j.ejmech.2015.04.040
  2. Ohsawa, I. et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13, 688-694 (2007). PMID:17486089;
    http://dx.doi.org/10.1038/nm1577
  3. Zhou, L. et al. Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. Brain Res 1517, 150-160 (2013). PMID:23603405;
    http://dx.doi.org/10.1016/j.brainres.2013.04.007

 

Inflammation

First recorded some two thousand years ago and now is accredited with some 4 million modern research papers identifying the challenges that inflammation represents, inflammation is often referred to as the root cause of disease and ultimately results in trillions of dollars of economic and social losses each and every year around the world.

Inflammation is a generic response of body tissue following damage to our cells or detecting potential damage effectors. Both infectious and non-infectious agents, as well as cellular injury, can activate an inflammatory response. The response is generic because it doesn’t distinguish between the possible causes. The inflammatory response removes harmful stimuli and initiates the healing process while involving immune and circulatory systems, however, it is a balancing act that can go awry.

Molecular Hydrogen supplementation acts against inflammation in two synergistic ways. First, oxidative stress can initiate or sustain an inflammatory response. Since Molecular Hydrogen is a powerful antioxidant, it suppresses the oxidative stress signal and in turn, reduces the risk of unnecessarily triggering or over sustaining an inflammatory response. Second, all pathways to inflammation pass through the activation of the NF-kB pathway. It is true in oxidative stress, and it is also true in the case of infection or chronic inflammation. Molecular hydrogen dampens the NF-kB pathway, directly avoiding a highly detrimental runaway inflammatory response.

Mitochondrial defects characterized by cytoplasmic calcium elevation, increased reactive oxygen species (ROS) levels, and pronounced release of pro-apoptotic factors and mitochondrial DNA (mtDNA) for example, are key stimulators of inflammatory response pathways. There is accumulating evidence showing an interconnection between defective energy metabolism and inflammasome hyperstimulation. Mitophagy prevents the defective removal of damaged mitochondria that leads to abnormal exacerbation of inflammation via the activation of the NF-kB pathway. Interestingly, although a mild increase in ROS production promotes mitophagy of defective mitochondria, very large increases bypass their safe removal. The key signal that determines whether or not a mitochondrion is defective, is the absence of polarization of the mitochondrial inner membrane indicative of a failure of the respiratory chain.

Supplementation with molecular hydrogen, maintains or helps restore the inner membrane polarisation by enabling proton pumping in complex I, all the while decreasing ROS production by the same complex and increasing ATP production. Furthermore, molecular hydrogen supplementation, promotes the expression of superoxide dismutase and catalase further decreasing the ROS level, as well as upregulating the PINK1/parkin pathway that enables mitophagy.

  1. Niu, Y. et al. Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch. Sci Rep 10, 1962 (2020). PMID:32029879;
    http://dx.doi.org/10.1038/s41598-020-58999-0
  2. Guan, W. J. et al. Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial. J Thorac Dis 12, 3448-3452 (2020). PMID:32642277;
    http://dx.doi.org/10.21037/jtd-2020-057
  3. Gkikas, I., Palikaras, K. & Tavernarakis, N. The Role of Mitophagy in Innate Immunity. Front Immunol 9, 1283 (2018). PMID:29951054;
    http://dx.doi.org/10.3389/fimmu.2018.01283
  4. Sim, M. et al. Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial. Sci Rep 10, 12130 (2020). PMID:32699287;
    http://dx.doi.org/10.1038/s41598-020-68930-2
  5. Chen, H. et al. Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy‑mediated NLRP3 inflammasome inactivation in sepsis. Int J Mol Med 44, 1309-1324 (2019). PMID:31432098;
    http://dx.doi.org/10.3892/ijmm.2019.4311
  6. Wu, X. et al. Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. Brain Res 1698, 89-98 (2018). PMID:29958907;
    http://dx.doi.org/10.1016/j.brainres.2018.06.028
  7. Yao, L., Chen, H., Wu, Q. & Xie, K. Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via PINK-mediated autophagy. Int J Mol Med 44, 1048-1062 (2019). PMID:31524220;
    http://dx.doi.org/10.3892/ijmm.2019.4264

 

NF-kB Protein Complex

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types. 

It is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation and bacterial or viral antigens. In addition, NF-κB plays a crucial role in regulating the immune response to infection. Thus, incorrect regulation of NF-κB is linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

The triggers of an inflammatory response are very diverse, including oxidative stress, each using a different path that converges to the Nuclear Factor Kappa B family of transcription factors.

Although the inflammatory response is essential, it can become self-sustaining and become a problem in itself. For example, inflammation causes oxidative stress, which itself causes inflammation. Self-perpetuating inflammation can lead to cancer development or cause chronic inflammatory diseases, of which there are many.

  1. Pires, B. R. B., Silva, R. C. M. C., Ferreira, G. M. & Abdelhay, E. NF-kappaB: Two Sides of the Same Coin. Genes (Basel) 9, E24 (2018). PMID:29315242;
    http://dx.doi.org/10.3390/genes9010024
  2. Liu, T., Zhang, L., Joo, D. & Sun, S. C. NF-κB signaling in inflammation. Signal Transduct Target Ther 2, 17023 (2017). PMID:29158945;
    http://dx.doi.org/10.1038/sigtrans.2017.23
  3. Liu, S. F. & Malik, A. B. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 290, L622-L645 (2006). PMID:16531564;
    http://dx.doi.org/10.1152/ajplung.00477.2005

 

Immune Cells

Long-lasting immune challenges such as chronic inflammation or chronic illness such as cancer result in abnormally high exhaustion rates of immune cells that ultimately lead to their death. Recently, Scharping et al. (2021)1 demonstrated that immune cell exhaustion was caused by mitochondrial dysfunction associated with increased reactive oxygen species, such as the hydroxyl radical. Interestingly, Chen et al. (2020)2 demonstrated that just two weeks of molecular hydrogen inhalation could reactivate normal levels of exhausted immune cells in stage III and IV cancer patients.

  • At the start of the study, the patient presented with abnormally high levels of exhausted cytotoxic T cells, senescent cytotoxic T cells, and killer Vδ1 cells, and abnormally low level of functional helper and cytotoxic T cells, Th1, total natural killer T cells, natural killer, and Vδ2 cells.
  • After two weeks of molecular hydrogen inhalation, the number of exhausted and senescent cytotoxic T cells decreased to within the normal range, and there was an increase in killer Vδ1 cells.
  • All the while, T cells, Th1, total natural killer T cells, natural killer, and Vδ2 cells subsets increased to within the normal range.

Immune cell exhaustion is linked to a decrease in mitophagy and an accumulation of dysfunctional depolarised mitochondria. Yet again we see that supplementation with molecular hydrogen, maintains or helps restore the mitochondrial inner membrane polarisation by enabling proton pumping in complex I, all the while decreasing ROS production by the same complex and increasing ATP production. Furthermore, molecular hydrogen supplementation promotes the expression of superoxide dismutase and catalase further decreasing the ROS level, as well as upregulating the PINK1/parkin pathway that enables mitophagy.

  1. Scharping, N. E. et al. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nat Immunol 22, 205-215 (2021). PMID:33398183;
    http://dx.doi.org/10.1038/s41590-020-00834-9
  2. Chen, J. B. et al. Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study. Med Gas Res 10, 149-154 (2020). PMID:33380580;
    http://dx.doi.org/10.4103/2045-9912.304221
  3. Yu, Y. R. et al. Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. Nat Immunol 21, 1540-1551 (2020). PMID:33020660;
    http://dx.doi.org/10.1038/s41590-020-0793-3
  4. Li, W. & Zhang, L. Rewiring Mitochondrial Metabolism for CD8+ T Cell Memory Formation and Effective Cancer Immunotherapy. Front Immunol 11, 1834 (2020). PMID:32983095;
    http://dx.doi.org/10.3389/fimmu.2020.01834
  5. Chen, H. et al. Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy‑mediated NLRP3 inflammasome inactivation in sepsis. Int J Mol Med 44, 1309-1324 (2019). PMID:31432098;
    http://dx.doi.org/10.3892/ijmm.2019.4311
  6. Li, W. & Zhang, L. Rewiring Mitochondrial Metabolism for CD8+ T Cell Memory Formation and Effective Cancer Immunotherapy. Front Immunol 11, 1834 (2020). PMID:32983095;
    http://dx.doi.org/10.3389/fimmu.2020.01834
  7. Wu, X. et al. Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. Brain Res 1698, 89-98 (2018). PMID:29958907;
    http://dx.doi.org/10.1016/j.brainres.2018.06.028
  8. Yao, L., Chen, H., Wu, Q. & Xie, K. Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via PINK-mediated autophagy. Int J Mol Med 44, 1048-1062 (2019). PMID:31524220;
    http://dx.doi.org/10.3892/ijmm.2019.4264

The Beneficial Action of Molecular Hydrogen

Since 2007 there have been around 2,000 research papers demonstrating that Molecular Hydrogen has both anti-oxidant and anti-inflammatory effects throughout a broad range of biological applications and species.

Molecular Hydrogen acts as a powerful antioxidant in biological systems both directly and indirectly. Directly by scavenging some Reactive Oxygen Species and indirectly by boosting our natural antioxidant system. Hydrogen alone consists only of one electron and one proton, but it is in its molecular form H2 that we see amazing biological significance. Molecular Hydrogen is the smallest molecule in our universe and thus can diffuse passively throughout a body, reaching every part of every cell where larger antioxidants cannot.

Molecular Hydrogen dampens the NF-kB pathway in normal cells, helping to bring about healing by decreasing inflammation. Molecular Hydrogen activates an alternate NF-kB pathway in cancerous cells enabling their apoptosis and limiting their capacity to multiply by cell division and infiltrate new tissues. Hydrogen atoms generally represent 62% of all the atoms in terrestrial bodies. That’s more than 3 out of every 5.

  • Molecular Hydrogen improves the normal functioning of the mitochondria.
  • Molecular Hydrogen is nature’s own potent anti-oxidant.
  • Molecular Hydrogen manages oxidative stress.
  • Molecular Hydrogen acts as an anti-inflammatory.
  • Molecular Hydrogen decreases proinflammatory cytokines.
  • Molecular Hydrogen assists in avoiding cytokine storms.
  • Molecular Hydrogen regulates the action of the NF-kB transcription factor.
  • Reactivation of exhausted immune cells

We believe that the biological relevance of Molecular Hydrogen represents the single most important technology on the planet today.

  1. Ohta, S. Recent progress toward hydrogen medicine: potential of molecular hydrogen for preventive and therapeutic applications. Curr Pharm Des 17, 2241-2252 (2011). PMID:21736547;
    http://dx.doi.org/10.2174/138161211797052664
  2. Sim, M. et al. Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial. Sci Rep 10, 12130 (2020). PMID:32699287;
    http://dx.doi.org/10.1038/s41598-020-68930-2

 

The Industries and Markets

Our entire planet awaits the biological benefit potential of molecular hydrogen and Oxygen supplementation on what will be a grand scale. In poultry, fish, animals, humans, etc… Molecular Hydrogen has been shown to significantly improve mitochondrial function, ATP production, the immune response, decrease oxidative stress, reduce and manage inflammation, considerably improve growth rate, and enhance disease resistance capabilities.

Hydrogen supplementation can improve the health, growth rate and feed conversion ratio of livestock such as poultry, where a 10-15% increase in weight can be achieved along with an improvement in meat quality while decreasing stimulant and biotic intervention. In aquatic species, increased yields of 30-40% are seen as growth rates rise and mortality decreases.

In plants, treatment with hydrogen-enriched water increases yield, salt and heavy metal resilience, flowering potential and fruit set. An increase in H2 in the rhizosphere leads to beneficial impacts for subsequent plant growth resulting in a 15–48% biomass increase in plants and is being termed as a hydrogen fertilization effect. Throughout all agricultural endeavours, it represents a low-cost solution to improve nutritional content and enhance production under abiotic stresses, such as drought and salinity. It will enable productivity from millions of hectares of land otherwise thought lost for various reasons, as well as the ability to regenerate the environment such as is required by environmentally destructive enterprises such as mining.

The following represents just a few of the many fields requiring the practical application research this technology will influence over the coming years.

Medical

 

There is a collection of data being actively researched worldwide with consistent results from a diverse range of independently funded organisations. The basic science is sound, and interest is accelerating into the specifics. Practical solutions and detailed data are still required across a broad range of fields. These future investigations may provide answers to challenges that remain elusive to current efforts and existing technologies, but it is only if we investigate it, that we will discover the answer.

 

There is ample evidence of the efficacy of Molecular hydrogen in Medicine, be it alone or in association with current treatments. In many instances, Molecular hydrogen improves dis-eased states that until now have been referred to as incurable, such as the many autoimmune disorders that are almost commonplace throughout the world today. Thus, there is great anticipation to advance the practical application of molecular hydrogen and oxygen supplementation throughout this sector.

 

For example, two weeks of Molecular Hydrogen inhalation led to the reactivation of exhausted CD4+, CD8+, γδ T cells, and NK cells in stage III and IV cancer patients, but of course the beneficial effect of hydrogen does not stop there. Hydrogen supplementation is also directly linked to improved general health and resistance to minor ailments, radiation exposure recovery, the reduction of adverse events from procedures or medications, the reduction of bacterial load and sepsis, and the improvement of cognitive function associated with mental illnesses and decline.

 

Furthermore, molecular hydrogen and oxygen supplementation have shown life-changing biological improvement of skin conditions, joint inflammation, mental health and fertility. The vast benefit of molecular hydrogen in biology appears to be linked to its positive action on the normal function of the mitochondria, a cellular organelle central to cellular energy production and cell proliferation. The evolutionary link between modern mitochondria and hydrogenosomes, and the recent discovery of H2-evolution in higher plant mitochondria will probably be key to our understanding of the molecular mechanism involved.

 

 

  1. Yang, M. et al. Hydrogen: A Novel Option in Human Disease Treatment. Oxid Med Cell Longev 2020, 8384742 (2020). PMID:32963703; http://dx.doi.org/10.1155/2020/8384742
  2. Chen, J. B. et al. Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study. Med Gas Res 10, 149-154 (2020). PMID:33380580; http://dx.doi.org/10.4103/2045-9912.304221
  3. Ge, L., Yang, M., Yang, N. N., Yin, X. X. & Song, W. G. Molecular hydrogen: a preventive and therapeutic medical gas for various diseases. Oncotarget 8, 102653-102673 (2017). PMID:29254278; http://dx.doi.org/10.18632/oncotarget.21130
  4. Satoh, Y. The Potential of Hydrogen for Improving Mental Disorders. Curr Pharm Des 27, 695-702 (2021). PMID:33185151; http://dx.doi.org/10.2174/1381612826666201113095938
  5. Zhu, Q. et al. Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep 8, 8051 (2018). PMID:29795283; http://dx.doi.org/10.1038/s41598-018-26388-3

Food & Agriculture

The global agriculture market is expected to rise from just under $10 trillion in 2019/20 and reach just over $12 trillion by 2025. It is known that Molecular hydrogen and oxygen availability in soil has plant growth-promoting properties. Furthermore, molecular hydrogen soil treatment will lead to further development of microbiota diversity within the soil, thus improving the overall health, fertility and disease resistance potential while promoting plant growth simultaneously. The ascendancy of bacterium further promotes the formation of complex biofilms in the soil, enabling carbon sequestration into the soil from the atmosphere. This has enormous implications when considering the regeneration of lost productive farmland and can significantly ameliorate further destruction of existing stressed pastures and ecosystems.

There is an immense potential associated with hydrogen and oxygen biology technology, and it presents viable solutions to advance government objectives in several of the key areas associated with feeding the world. This technology will not only assist in the volume of goods produced, but also the quality of the goods, the post-harvest lifespan, the nutritional content, the ability to better resist environmental events, the ability to better resist biological attack, and significantly improve reputations as a preferred product of choice. Further to this, hydrogen and oxygen supplementation applications demonstrate remarkable improvements in drought tolerance, salinity resistance, dis-ease resistance, lower water allocation requirements, improved soil life and more robust, healthier livestock. It is expected that the technology will offer more products with greater nutritional content, at a higher price, with less risk.

It is understood that consumers of the future will want to know more about where their food has come from and that they will want Hydrogen based farming certifications similarly to what we see in the “Organically Certified” spaces. The technology affords significant value towards farm biodiversity certification and carbon capture schemes, will set new standards worldwide, and give farmers and enterprises considerable advantage and preference throughout the global marketplace. Current evidence suggests significant benefits and advancement for live export, red meat, white meat, seafood and plant industries alike. The global meat, poultry and seafood market is expected to grow from around $1.4 trillion in 2020 to just under $2 trillion in 2025.

Improving yields and decreasing losses is a focus of all agricultural enterprises, which is now more critical than ever before. Since molecular hydrogen supplementation can result in the production of ATP decoupled from the nutrient intake, more energy can be invested into growth without an increase in nutrient intake. It is why, for example, molecular hydrogen supplementation is associated with an improvement in food conversion ratio, and improved plant growth.

Clean, natural and completely organic in every sense, molecular hydrogen and oxygen supplementation allows crops, animals and produce to grow in otherwise unproductive soil – allowing millions of hectares of farmland to re-enter the market and contribute to addressing the emerging global issues surrounding food security. The biological improvement that can be achieved in this sector has many consequential benefits to the market, including further health benefits to the consumer accessing higher quality protein sources with less pharmaceutical or chemical inputs.

Attractive research opportunities include plant protein, Dairy, animal protein, disease resistance, soil biodiversity, carbon capture, environmental repair, water management, soil regeneration, salinity resistance, drought tolerance, post-harvest ripening, and extreme weather event resistance and recovery, amongst others.

  1. Wang, Y. Q., Liu, Y. H., Wang, S., Du, H. M. & Shen, W. B. Hydrogen agronomy: research progress and prospects. J Zhejiang Univ Sci B 21, 841-855 (2020). PMID:33150769;
    http://dx.doi.org/10.1631/jzus.B2000386
  2. Li, C., Gong, T., Bian, B. & Liao, W. Roles of hydrogen gas in plants: a review. Funct Plant Biol 45, 783-792 (2018). PMID:32291062;
    http://dx.doi.org/10.1071/FP17301
  3. Xie, Y. et al. Hydrogen-rich water-alleviated ultraviolet-B-triggered oxidative damage is partially associated with the manipulation of the metabolism of (iso)flavonoids and antioxidant defence in Medicago sativa. Funct Plant Biol 42, 1141-1157 (2015). PMID:32480752;
    http://dx.doi.org/10.1071/FP15204
  4. Wu, Q., Su, N., Cai, J., Shen, Z. & Cui, J. Hydrogen-rich water enhances cadmium tolerance in Chinese cabbage by reducing cadmium uptake and increasing antioxidant capacities. J Plant Physiol 175, 174-182 (2015). PMID:25543863;
    http://dx.doi.org/10.1016/j.jplph.2014.09.017
  5. Lin, Y. et al. Hydrogen-rich water regulates cucumber adventitious root development in a heme oxygenase-1/carbon monoxide-dependent manner. J Plant Physiol 171, 1-8 (2014). PMID:24331413;
    http://dx.doi.org/10.1016/j.jplph.2013.08.009
  6. Dong, Z., Wu, L., Kettlewell, B., Caldwell, C. D. & Layzell, D. B. Hydrogen fertilization of soils–is this a benefit of legumes in rotation. Plant, Cell & Environment 26, 1875-1879 (2003). 10.1046/j.1365-3040.2003.01103.x

Aquaculture

Portland, OR, Jan. 13, 2021 (GLOBE NEWSWIRE) — According to the report published by Allied Market Research, the global fish farming market generated $271.61billion in 2018 and is projected to reach $376.48 billion by 2025, witnessing a CAGR of 4.7% from 2018 to 2025.

This highly susceptible industry has much to gain from the enrichment of molecular hydrogen and oxygen throughout the life cycle from hatchery to plate. However, it has not been until recent times that gas infusion technologies and devices have advanced to the point that large volumes of water can be supplemented with this life-giving gas to make this application viable.

The oxygenation of water is well known to increase biological activity, growth rate and yield potential however, increasing oxygen levels too high increases oxidative potential also leading to high-stress levels and catastrophic loss potential too. If oxygen levels are managed well, nanobubble infusion alone would improve feed conversion ratios and avoid mass death due to heat stress and adverse weather events, and is shown to be able to double the harvest potential when compared to classical aerators.

However, it is the molecular hydrogen inclusion into this mix of water supplementation at the nanobubble level that dramatically improves wound healing, antioxidant capacity and improve mitochondrial function once again translating into better feed conversion ratios by providing a supply of ATP decoupled from food intake. Moreover, Hu et al (2017) demonstrated that molecular hydrogen treatment dramatically improved the innate immune system in fish, thus improving disease resistance also.

  1. Hu, Z. et al. Impact of molecular hydrogen treatments on the innate immune activity and survival of zebrafish (Danio rerio) challenged with Aeromonas hydrophila. Fish Shellfish Immunol 67, 554-560 (2017). PMID:28630014;
    http://dx.doi.org/10.1016/j.fsi.2017.05.066
  2. Rahmawati, A. I. et al. Enhancement of Penaeus vannamei shrimp growth using nanobubble in indoor raceway pond. Aquaculture and Fisheries 6, 277-282 (2021). 10.1016/j.aaf.2020.03.005
  3. Tanaka, Y., Xiao, L. & Miwa, N. Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum. Med Gas Res 12, 91-99 (2022). PMID:34854419;
    http://dx.doi.org/10.4103/2045-9912.330692
  4. Blier, P. Fish Health: An Oxidative Stress Perspective. Fisheries and Aquaculture Journal 05, (2014). 10.4172/2150-3508.1000e105
  5. Secci, G. & Parisi, G. From farm to fork: lipid oxidation in fish products. A review. Italian Journal of Animal Science 15, 124-136 (2016). 10.1080/1828051x.2015.1128687

Desertification & Soil Rehabilitation

A top United Nations environment official said that forest fires, droughts, salinity, and other forms of land degradation cost the global economy as much as 15 trillion dollars every year and are deepening the climate change crisis. Ibrahim Thiaw, executive secretary of the U.N. Convention to Combat Desertification (UNCCD), said land degradation was shaving 10-17 per cent off the world economy, which the World Bank calculates at 85.8 trillion dollars.

Deforestation results in changes that will ultimately affect all of us. Changing the environment will, of course, change the climate in that environment. What used to live in the shade at 25 degrees Celsius now has to live in full sunlight at 35 degrees Celsius for example. Everything we are relies on our planetary layer of organic insulation and the gasses it produces. All life requires a favourable environment towards its preferred bias, and to alter that, means change.

Ultimately, environment change is the cause, and climate change is the consequence.

Strains of a particular bacteria of significant interest, such as Variovorax paradoxus, can be categorised into two groups, hydrogen oxidisers and heterotrophic strains, both of which are aerobic and enjoy the availability of oxygen around it. The diverse metabolic capabilities enable it to degrade a wide array of organic pollutants, including aliphatic polycarbonates and polychlorinated biphenyls. V-paradoxus is involved in cycling numerous inorganic elements, including arsenic, sulphur, manganese and rare earth elements in a range of soil and freshwater. The species is also tolerant of many heavy metals, including cadmium, chromium, cobalt, copper, lead, mercury, nickel, silver, and zinc.

It also promotes the formation of complex biofilm that enables carbon sequestration into the soil from the atmosphere. This has enormous implications when considering the regeneration of lost productive farmland and can significantly ameliorate further destruction of existing stressed pastures and ecosystems. The isolates of V-paradoxus found in both H2-treated soil and the soil adjacent to H2 producing soybean nodules had significant impact on plant growth. Furthermore, molecular hydrogen soil treatment will lead to further development of V. Paradoxus naturally within the soil, potentially improving the detoxification of contaminated soil while promoting plant growth.

The development of this knowledge represents an ability to repair farmland thought lost for generations and will enable regeneration and the ability to resume productive farming. We strongly encourage support into this space as we believe that the HBRC can play a major role in our planets agricultural biodiversity stewardship initiatives, and offer insight into potential not thought possible before now.

  1. Maimaiti, J. et al. Isolation and characterization of hydrogen-oxidizing bacteria induced following exposure of soil to hydrogen gas and their impact on plant growth. Environ Microbiol 9, 435-444 (2007). PMID:17222141;
    http://dx.doi.org/10.1111/j.1462-2920.2006.01155.x
  2. Piché-Choquette, S. & Constant, P. Molecular Hydrogen, a Neglected Key Driver of Soil Biogeochemical Processes. Appl Environ Microbiol 85, e02418-18 (2019). PMID:30658976;
    http://dx.doi.org/10.1128/AEM.02418-18
  3. Dong, Z., Wu, L., Kettlewell, B., Caldwell, C. D. & Layzell, D. B. Hydrogen fertilization of soils–is this a benefit of legumes in rotation. Plant, Cell & Environment 26, 1875-1879 (2003). 10.1046/j.1365-3040.2003.01103.x
  4. Li, C., Gong, T., Bian, B. & Liao, W. Roles of hydrogen gas in plants: a review. Funct Plant Biol 45, 783-792 (2018). PMID:32291062;
    http://dx.doi.org/10.1071/FP17301

Climate Change and Carbon Sequestration

Despite the many differing theories behind the reasons behind climate change, the evidence is agreed upon and that is that there is change, and something needs to be done.

Soil Carbon sequestration is one of the paths that can contribute significantly to carbon neutrality in the future while benefiting the agricultural sector the world over.

Following the lessons and regenerative solutions identified through soil regeneration and desertification management practices all now gaining favour, immense change is further possible in a very short period of time given the enormous significance molecular hydrogen and oxygen supplementation can provide using nanobubble infusion methods of our existing water infrastructure and supplies.

Increasing organic matter in the soil for example, by enabling larger plant root systems and allowing for the formation of extensive biofilms, improves soil structure and reduces erosion, leading to improved water quality in groundwater and surface waters, and ultimately, increased food security. Dong and Layzell (2001) have demonstrated that 3 weeks of soil hydrogen supplementation led to net CO2 fixation into the soil and increased oxygen consumption. While increased root length following hydrogen supplementation has been widely reported.

It can difficult to put a commercial dollar figure on the benefit of carbon sequestration, however done the right way, it can deliver tremendous economic benefit through sustainable increased agricultural production, both qualitatively and quantitatively. Ultimately, it is with the correct farming management practices and a regenerative focus, that carbon sequestration becomes an unavoidable solution. A net zero carbon footprint is of course a good place to start whereby we stop creating more, however, we still need to get it back into the ground where it belongs in the form of plants, trees and life. While nearly 50% of the atoms in a plant are hydrogen atoms, about 45% of its weight is carbon.

We acknowledge that reforms will empower farmers to diversify their income and earn credits under the various systems and incentives rolling out around the world for simply regenerating land and soil thought lost for whatever reason, but the ecosystem required to enable their regeneration also needs to start somewhere. Molecular hydrogen and oxygen enriched water significantly assists to create an environment in the soil capable of favouring life. Healing the planet will be profitable, not only in carbon credit accumulation but also to enable the production of goods in otherwise thought lost agricultural land. On a global scale these numbers are immense and the potential to scale and provide benefit is enormous.

  1. Dong, Z. & Layzell, D. B. H2 oxidation, O2 uptake and CO2 fixation in hydrogen treated soils. Plant and soil 229, 1-12 (2001). 10.1023/A:1004810017490
  2. Xie, Y. et al. Hydrogen-rich water-alleviated ultraviolet-B-triggered oxidative damage is partially associated with the manipulation of the metabolism of (iso)flavonoids and antioxidant defence in Medicago sativa. Funct Plant Biol 42, 1141-1157 (2015). PMID:32480752;
    http://dx.doi.org/10.1071/FP15204

Elite Performance & Recovery

Elite sports performance as well as the recovery after an event, are all dependant on the mitochondria. For example, exercise leads to nuclear translocation of PGC1-alpha to initiate mitochondrial biogenesis. in fact, the more PGC1-alpha available the more efficient is cellular respiration, with an increase in cells mitochondrial content. An increase in PGC-1alpha have been linked to improved cellular energy production and rapid clearance of lactate in the body. Interestingly Hydrogen supplementation upregulates PGC-1alpha in doing so it should promote performance and improve recovery as demonstrated by the work of Aoki et al. 2012.

Furthermore, hydrogen supplementation increases the mitochondrial production of ATP by more than 50% while decreasing the production of superoxide by complex I and increases the activity of superoxide dismutase and catalase. Finally, hydrogen scavenges the Hydroxyl radical as shown by Ohsawa et al (2007). The fact that Hydrogen supplementation not only increases ATP production by the mitochondria but can also lead to an increase in mitochondria numbers via its action on PGC-1alpha presage of tremendous benefit to elite performance.

  1. Summermatter, S., Santos, G., Pérez-Schindler, J. & Handschin, C. Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proc Natl Acad Sci U S A 110, 8738-8743 (2013). PMID:23650363;
    http://dx.doi.org/10.1073/pnas.1212976110
  2. Niu, Y. et al. Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch. Sci Rep 10, 1962 (2020). PMID:32029879;
    http://dx.doi.org/10.1038/s41598-020-58999-0
  3. Olesen, J., Kiilerich, K. & Pilegaard, H. PGC-1alpha-mediated adaptations in skeletal muscle. Pflugers Arch 460, 153-162 (2010). PMID:20401754;
    http://dx.doi.org/10.1007/s00424-010-0834-0
  4. Kamimura, N., Ichimiya, H., Iuchi, K. & Ohta, S. Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism. NPJ Aging Mech Dis 2, 16008 (2016). PMID:28721265;
    http://dx.doi.org/10.1038/npjamd.2016.8
  5. Ostojic, S. M., Vukomanovic, B., Calleja-Gonzalez, J. & Hoffman, J. R. Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgrad Med 126, 187-195 (2014). PMID:25295663;
    http://dx.doi.org/10.3810/pgm.2014.09.2813
  6. Aoki, K., Nakao, A., Adachi, T., Matsui, Y. & Miyakawa, S. Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Med Gas Res 2, 12 (2012). PMID:22520831;
    http://dx.doi.org/10.1186/2045-9912-2-12
  7. Todorovic, N., Javorac, D., Stajer, V. & Ostojic, S. M. The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and Soreness Perception in Young Men Subjected to High-Intensity Eccentric Exercise. J Sports Med (Hindawi Publ Corp) 2020, 8836070 (2020). PMID:33123594;
    http://dx.doi.org/10.1155/2020/8836070
  8. Ishihara, G., Kawamoto, K., Komori, N. & Ishibashi, T. Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced mitochondrial membrane potential. Biochem Biophys Res Commun 522, 965-970 (2020). PMID:31810604;
    http://dx.doi.org/10.1016/j.bbrc.2019.11.135
  9. Ohsawa, I. et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13, 688-694 (2007). PMID:17486089;
    http://dx.doi.org/10.1038/nm1577

Prevention and Longevity

Ageing goes hand in hand with increased oxidative damage to cells leading toward cellular decline and organ dysfunction. Indeed, Schriner et al. (2005) have shown that an increase in antioxidant defence in the mitochondria, the main producer of reactive oxygen species, extend life. Most importantly ageing is associated with specific diseases that we attempt to address only after their onset. However, as for everything, prevention is often the best course of action. Yamamoto et al (2021) highlight this and advocate for the preventative use of molecular hydrogen against pre-symptomatic diseases.

One core example is immunosenescence brought about by chronic inflammation and a chronic pro-inflammatory state. Most, if not all, degenerative and age-related diseases can be linked to mitochondrial dysfunction and associated elevated oxidative stress. Molecular hydrogen promotes mitochondrial function by increasing ATP production and influencing metabolic pathways away from glycolysis and toward oxidative phosphorylation.

Molecular hydrogen’s antioxidant, anti-inflammatory and immuno-restorative action is documented and lacks deleterious side effects, making it a prime candidate for the preventive treatment of pre-symptomatic diseases. Because H2 diffuse rapidly in the organism reaching every mitochondrion in the body molecular hydrogen can act as a protectant to all pre-symptomatic diseases at the same time and indiscriminately before the onset of symptoms.

  1. Kamimura, N., Ichimiya, H., Iuchi, K. & Ohta, S. Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism. NPJ Aging Mech Dis 2, 16008 (2016). PMID:28721265;
    http://dx.doi.org/10.1038/npjamd.2016.8
  2. Hara, F. et al. Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells. Circ J 80, 2037-2046 (2016). PMID:27477846;
    http://dx.doi.org/10.1253/circj.CJ-16-0227
  3. Tomofuji, T. et al. Effects of hydrogen-rich water on aging periodontal tissues in rats. Sci Rep 4, 5534 (2014). PMID:24985521;
    http://dx.doi.org/10.1038/srep05534
  4. Cutler, R. G. Antioxidants and aging. The American Journal of Clinical Nutrition 53, 373S-379S (1991).
  5. Schriner, S. E. et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308, 1909-1911 (2005). PMID:15879174;
    http://dx.doi.org/10.1126/science.1106653
  6. Jaul, E. & Barron, J. Age-Related Diseases and Clinical and Public Health Implications for the 85 Years Old and Over Population. Front Public Health 5, 335 (2017). PMID:29312916;
    http://dx.doi.org/10.3389/fpubh.2017.00335
  7. Yamamoto, H. et al. Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases. Int J Mol Sci 22, 7211 (2021). PMID:34281264;
    http://dx.doi.org/10.3390/ijms22137211

What Does It Mean For All Of Us?

When considering productivity increases, cost reduction, soil regeneration and health, disease reduction, and total economic benefit on a global scale, the numbers are staggering. The progression towards this technology is inevitable, and in these very challenging times, the need is pressing and relevant for all governments the world over.

Significant financial support towards this critical research endeavour will allow momentous, unhindered progress towards clean, natural, and effective core solutions to address the precarious state of our fellow inhabitants, the food chain and the environment. What this technology proposes is genuinely game-changing for so many on what will be a massive scale.

Hydrogen and oxygen have been intrinsically involved with the evolution of life in both prokaryotes and eukaryotes (e.g. hydrogenases, hydrogenosomes, mitochondria, etc.). We are at the leading edge of a new understanding of biology, and unsurprisingly there is still much to learn. Nonetheless, a common theme has emerged: the supplementation of Molecular Hydrogen into the biological system has a complementary beneficial effect on the entire system. As you can see, there is a vast range of options and potentials that could all benefit us in both the long and short term, and there are several strategic ways we could look at this.

Many of us are mentally and emotionally challenged when we see things like a 2 or 3 million dollar playground funded by the government, $127 million for a traffic roundabout, or $180 million for an upgrade to an existing function centre in a small remote city. While we fully appreciate that these are all good things that strengthen our communities, workforce and infrastructure capabilities, they all pale when compared to the significance and return of the advancement this technology represents.

There are trillions and trillions of dollars at stake here, and the world as a whole has an opportunity to mediate and address obvious solution potentials in extremely troubling times and an increasingly uncertain future ahead.

  • Both the quality and quantity of food need to be secured.
  • We need to manage the soils and inputs from where this life-giving sustenance comes from.
  • We need to manage the runoff of these inputs into our environment.
  • Improve the overall environmental protection and sustainability potential for future generations.
  • Prevention from disease in high-density farming environments.
  • Opening our borders and economies while protecting our families and children.
  • Reduce human disease and improve productivity.
  • Reduce healthcare costs to the government and society.
  • Rectify upstream processes and management systems to reduce runoff that challenges our waterways and reefs such as what is happening to Australia’s Great Barrier Reef.
  • Massively improve the ability to resist external international pressures and vulnerabilities.
  • Create an entire industry and advance manufacturing capabilities.
  • Create and secure tens, if not hundreds of thousands of jobs.
  • Massive reduction in the cost of Health Care.

Hydrogen Biology Research Centre

The Hydrogen Biology Research Centre has been established to define the detailed application information that will allow broad implementation of this evolutionary and revolutionary improvement in biological management and supplementation. Situated in Northern Australia and on the doorstep of life between The Great Barrier Reef, the world-renowned Daintree Rainforest, and the rich agricultural region of the Atherton Tablelands, its isolation and proximity are both challenges and assets in their own unique way.

The purpose of the Hydrogen Biology Research Centre (HBRC) is to further “Applied Research” in the biological use of Hydroxygen, the gaseous electrolysed form of H20 (pure water).

The benefit of moderate supplementation of oxygen is well established; however, since a seminal paper published in 2007, the number of reported benefits of molecular hydrogen in biological systems has been tremendous. Indeed, molecular hydrogen supplementation in the form of Hydrogen gas or Hydrogen enriched water has proven beneficial in the domains of human and animal health as well as plant growth and resistance to abiotic stresses. From aquaculture and marine life to the microbial abundance and diversity in soil, environmental remediation and regeneration, as well as carbon sequestration from the atmosphere to the earth, this research field is still young, and due to its immense potential benefits, needs to be nurtured, understood, and refined.

The HBRC’s primary focus is to apply this science to the vast array of challenges and applications that modern science is still unable to resolve. The HBRC will engage and collaborate with the many Governments, globally influential leaders, charitable organisations and research institutes worldwide to apply real-life clinical and practical solutions facing much of humanity, our earth’s co-inhabitants, and the environments in which they live.

The Hydrogen Biology Research Centre is a not-for-profit organisation, and all funds raised for a particular project are dedicated to that specific project and outcome. A global scientific community is encouraged to engage and contribute towards this immense undertaking across the many associated fields of expertise with real-world solutions the ultimate objective.

We passionately and respectfully request support from everyone everywhere, and to come with us as we make the world a better place through clean, natural, biologically proven fundamental science for the greater good of all life that is so interdependent. Please support us however you are able, in whatever capacity you can, as it will be our strength as one, where our momentum will create the biggest difference. Make no mistake, we are all in this together, and we will all benefit from what is created here.

Regardless of what we do or do not do, hydrogen will still be at the core of life itself, and no matter what path any of us take, hydrogen by count will remain the single biggest piece of any biological puzzle.

From little things – big things come.

Please donate here if you can.

Or contact us and see how we can work together.


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