
Ageing goes hand in hand with increased oxidative damage to cells leading toward cellular decline and organ dysfunction. Indeed, Schriner et al. (2005) have shown that an increase in antioxidant defence in the mitochondria, the main producer of reactive oxygen species, extend life. Most importantly ageing is associated with specific diseases that we attempt to address only after their onset. However, as for everything, prevention is often the best course of action. Yamamoto et al (2021) highlight this and advocate for the preventative use of molecular hydrogen against pre-symptomatic diseases.
One core example is immunosenescence brought about by chronic inflammation and a chronic pro-inflammatory state. Most, if not all, degenerative and age-related diseases can be linked to mitochondrial dysfunction and associated elevated oxidative stress. Molecular hydrogen promotes mitochondrial function by increasing ATP production and influencing metabolic pathways away from glycolysis and toward oxidative phosphorylation.
Molecular hydrogen’s antioxidant, anti-inflammatory and immuno-restorative action is documented and lacks deleterious side effects, making it a prime candidate for the preventive treatment of pre-symptomatic diseases. Because H2 diffuse rapidly in the organism reaching every mitochondrion in the body molecular hydrogen can act as a protectant to all pre-symptomatic diseases at the same time and indiscriminately before the onset of symptoms.
- Kamimura, N., Ichimiya, H., Iuchi, K. & Ohta, S. Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism. Npj Aging Mech Dis 2, 16008 (2016).
- Hara, F. et al. Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells. Circ J 80, 2037–2046 (2016).
- Tomofuji, T. et al. Effects of hydrogen-rich water on aging periodontal tissues in rats. Sci Rep-uk 4, 5534 (2014).
- Cutler, R. G. Antioxidants and aging. Am J Clin Nutrition53, 373S-379S (1991).
- Schriner, S. E. et al. Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria. Science 308, 1909–1911 (2005).
- Jaul, E. & Barron, J. Age-Related Diseases and Clinical and Public Health Implications for the 85 Years Old and Over Population. Front Public Health 5, 335 (2017).
- Yamamoto, H. et al. Molecular Hydrogen as a Novel Protective Agent against Pre-Symptomatic Diseases. Int J Mol Sci 22, 7211 (2021).